One-in-a-million people are living with EHE worldwide.

Our mission is to find treatments and a cure for epithelioid hemangioendothelioma (EHE) by advancing research and driving collaboration among patients, researchers, and clinicians.

We envision a world where Epithelioid Hemangioendothelioma (EHE) is easily diagnosed and treatable. Join our dedicated community by subscribing to our emails.

Patient-Powered EHE Research

EHE Biobank

Patients are the key to finding new treatments for EHE! Researchers need tumor tissue and fluid from EHE patients to understand disease progression and speed the development of new drugs and therapies.

EHE Global Patient Registry

The EHE Global Patient Registry empowers people with Epithelioid Hemangioendothelioma (EHE) to join together to improve our understanding of this ultra-rare sarcoma. We need every EHE patient to join this critical tool used to support researchers searching for treatments and a cure for EHE.

Latest EHE News, Events and Research

Poker Tournament in Memory of Brian Frank Raises $11,000

By EHE Foundation | October 31, 2016

Earlier this month, Angela Osborn, along with numerous family and friends, gathered for a night of poker in Washington in order to honor her late brother Brian Frank. Along with the poker tournament, a silent auction was held, T-shirts and sweatshirts featuring Brian’s initials and birthdate were sold, and at the end of the evening, a staggering $11,000 […]

Smoothie King Raises Money in Memory of Mandy O’Connor

By EHE Foundation | October 30, 2016

Smoothie King in York, Pennsylvania, held its second fundraiser in memory of Mandy O’Connor on October 13. Sean and Nicky Krebs, Smoothie King franchisees and close friends of Mandy and Devin’s, once again donated 50 percent of their sales on what would have been Mandy’s 33rd birthday. Mandy died due to EHE on April 5, […]

The Hershey Company Donates to EHE Research

By EHE Foundation | October 30, 2016

The Hershey Company has made a generous donation to The EHE Foundation. The world-famous confections company in Pennsylvania gave $500 to support ongoing research efforts into the rare cancer. The Foundation would like to thank Hershey employee Serena Wang for the support. Serena was a personal friend of Mandy O’Connor, who died from EHE in […]

Stay up to Date on EHE by Reading The Pledge: Sixth Edition

By EHE Foundation | October 30, 2016

EHE is no longer some unknown rare cancer! The grassroots movement to raise awareness and help fund EHE research is now a worldwide effort! Thanks to Hugh Leonard, director of The EHE Rare Cancer Charity UK, for assembling EHE stories for the sixth edition of The Pledge. Download The Pledge here.

The EHE Foundation Advisory Board

By EHE Foundation | September 26, 2016

Meet the Men & Women Fighting EHE in the Lab

The EHE Foundation Receives $10,000 Donation

By EHE Foundation | September 26, 2016

The Bock Foundation, the philanthropic arm of Ernest Bock & Sons, Inc., a construction and hospitality conglomerate in Pennsylvania, has been making substantial contributions to charitable causes for decades. Back in 1992, a Bock employee was tragically killed in an automobile accident. The Bock family aided in funeral expenses, and quickly realized the organization could […]

Advocacy in Action: ESMO Sarcoma and Rare Cancers Congress & EHE Research Meeting

By Maggie Cameron | April 8, 2026

In March, EHE Foundation was represented at two important meetings in Europe focused on sarcoma, rare cancers, and EHE research. These gatherings were invaluable opportunities to connect with clinicians, researchers, and fellow advocates working to improve care, deepen understanding, and advance progress for people affected by EHE. Executive Director Denise Robinson attended on behalf of […]

Across Borders and Histologies: Rethinking Endpoints for Vascular Sarcoma Trials

By Kristianne Oristian, PhD | April 8, 2026

Following the publication of results from a phase 2 study of eribulin in two vascular sarcomas, angiosarcoma and EHE, Dr. Tom Chen of National Taiwan University College of Medicine shared commentary in Clinical Cancer Research. He praised the investigators for their collaborative study while also pointing to important considerations for future research. Although angiosarcoma and […]

EHE Foundation Awards $335,000 in New Research Grants to Advance Progress in EHE

By EHE Foundation | March 16, 2026

The EHE Foundation is proud to announce $335,000 in funding through the 2026 EHE Foundation Research Grants Program to support two innovative research projects in epithelioid hemangioendothelioma (EHE). Selected for their scientific merit, potential impact, and clinical relevance, these projects address two important priorities in EHE research: biomarker development and new therapeutic approaches. Together, they […]