Clinical Trials

Below is a continuously updated list of active clinical trials that include people diagnosed with EHE. Additional details and contacts for each study are available at the ClinicalTrials.gov identifier.

  • When considering a trial, consult your physician and the trial team to address any questions.
DescriptionTrial No.Sponsor
Two-part, First-in-Human Study on ODM-212 in Subjects with Selected Advanced Solid Tumours (TEADES)NCT06725758Orion Pharma
SARC046: A Phase II Trial of Nab-Sirolimus in Patients With Progressing or Symptomatic Epithelioid HemangioendotheliomaNCT07104331Sarcoma Alliance for Research through Collaboration
Phase I Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors Enriched for Tumors With NF2 or mNF2 Gene MutationsNCT04665206Vivace Therapeutics
A Trial of ABSK043, an Oral PD-L1 Inhibitor, in Patients With Angiogenic Sarcomas NCT07014137University Health Network, Toronto
The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN) (EHE)NCT06408441Fondazione IRCCS Istituto Nazionale dei Tumori
A Study of BGC515 Capsules in Subjects With Advanced Solid TumorsNCT06452160BridGene Biosciences
Epithelioid Haemangioendothelioma Observational StudyNCT06680401Fondazione IRCCS Istituto Nazionale dei Tumori Milano
NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)NCT06239272St. Jude Children's Research Hospital

A clinical trial is a type of research that studies a test, treatment, or other intervention according to a research plan. This may include drugs that are not yet approved by the FDA, drugs that are already approved and are being investigated for new or different purposes, comparisons of drugs, devices or procedures, or other types of interventions.

Phase 1 clinical trials (studies) are the first step in testing new drug candidates in humans. These studies are done primarily to test safety, side effects, and the best dose of a potential new treatment. Some study participants may benefit from the drug candidate being tested; however, disease response is not the primary purpose of phase 1 studies.

Observational studies are another type of research study where doctors assess the health outcomes of participants. These studies are done as a part of routine care and help researchers understand the effects of a treatment, procedure, or other lifestyle change. 

When considering participation in a clinical trial or any other research we urge you to consult your physician or other qualified medical resource as well as the person who is conducting the research study to answer any questions you have. The information provided here is for information only and is not intended as medical advice or a recommendation. 

EHE 360 Connect Recording: Clinical Trials for EHE

Greg Cote, MD, PhD, medical oncologist, and early-stage clinical trialist from Mass General Cancer Center joined us on July 27, 2024, to provide an in-depth look at the drug development process and discuss the landscape of clinical trials that include patients with epithelioid hemangioendothelioma (EHE).

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EHE 360 Global Patient Conference Recording: Clinical Trials

Dr. Mrinal Gounder is a sarcoma medical oncologist and a clinical trialist in early drug development at Memorial Sloan Kettering Cancer Center. In this recording from April 10, 2025, he shares limited data showing encouraging results from the VT3989 TEAD inhibitor clinical trial that includes EHE patients.

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Stay Informed

Quarterly newsletters to the EHE Collaborative Research Network (EHE CRN) provide firsthand information about our research program, advances in EHE research, and opportunities to collaborate with our professional and patient communities.