Clinical Trials

A clinical trial is a type of research that studies a test, treatment, or other intervention according to a research plan. This may include drugs that are not yet approved by the FDA, drugs that are already approved and are being investigated for new or different purposes, comparisons of drugs, devices or procedures, or other types of interventions. 

Observational studies are another type of research study where doctors assess health outcomes of participants. These studies are done as a part of routine care and help researchers understand the effects of a treatment, procedure or other lifestyle change. 

When considering participation in a clinical trial or any other research we urge you to consult your physician or other qualified medical resource as well as the person who is conducting the research study to answer any questions you have. The information provided here is for information only and is not intended as medical advice or a recommendation. 

Below are currently active clinical trials of EHE in the United States. To see the details and contacts for each study, click on the ClinicalTrials.gov identifier.

To learn more about the phases of clinical trials go to cancer.org.

ClinicalTrials.gov IdentifierStudy Title / PhaseLocation(s)Principal Investigator
NCT04028063Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas - Phase 2Aurora, ColoradoBreelyn Wilky, MD
NCT04784247Lenvatinib and Pembrolizumab in People with Advanced Soft Tissue Sarcoma - Phase 2NY & NJ LocationsSandra D'Angelo, MD
NCT03331250Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE) - Phase 2Boston, MAGregory Cote, MD, PhD
NCT04577014INCMGA00012 (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients with Advanced Soft Tissue Sarcoma - Phase 1/2New York, NYSandra D'Angelo, MD

Phase 1 Clinical Trials

Phase 1 clinical trials (studies) are the first step in testing new drug candidates in humans. These studies are done primarily to test safety, side effects, and the best dose of a potential new treatment. Some study participants may benefit from the drug candidate being tested; however, disease response is not the primary purpose of phase 1 studies. To find out more about these studies, contact our research team.

To learn more about the phases of clinical trials go to cancer.org.

ClinicalTrials.gov IdentifierStudy Title / PhaseLocation(s)
NCT05228015Phase I Study: Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects With Advanced Solid TumorsMultiple Locations
NCT04857372Phase I Study: IAG933 in Patients With Advanced Mesothelioma and Other Solid TumorsMultiple Locations