EHE Library

The EHE library includes publications and articles about EHE research and treatments, as well as other relevant topics that are available online. Some articles are free with open access and others require subscription.

If you have an article to add or any questions, please contact us at research@fightehe.org.

Lastest Publications

Featured Article

Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts
This consensus paper provides key recommendations on the management of epithelioid hemangioendothelioma (EHE). Recommendations followed a consensus meeting of a multidisciplinary group of experts from different institutions from Europe, North America and Asia, as well as representatives from the ESMO Faculty, EURACAN, PAEDCAN, GENTURIS, EHE UK/US patient advocates and SPAEN. Thank you to Dr. Silvia Stacchiotti for her leadership and guidance of this groundbreaking resource!

Title of ArticleLink to ArticlePublication YearKey Words
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendotheliomahttp://genesdev.cshlp.org/content/35/7-8/4952021fusion, TAZ, CAMTA1
P10015/SARC033: A phase 2 trial of trametinib in patients with advanced epithelioid hemangioendothelioma (EHE)https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.115032021clinical trial
The heterogeneity of Epithelioid Hemangioendothelioma (EHE): A case series and review of the literature with emphasis on treatment optionshttps://www.sciencedirect.com/science/article/pii/S0093775421000269?via%3Dihub2021hepatic, treatment
Supportive care needs of patients living with an extremely rare and unpredictable cancer: The Epithelioid Haemangioendothelioma patient experiencehttps://onlinelibrary.wiley.com/doi/10.1111/ecc.134612021symptoms
WWTR1(TAZ)-CAMTA1 gene fusion is sufficient to dysregulate YAP/TAZ signaling and drive epithelioid hemangioendothelioma tumorigenesishttp://genesdev.cshlp.org/content/35/7-8/512.abstract2021fusion, YAP, TAZ, CAMTA1
TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complexhttps://elifesciences.org/articles/628572021fusion, YAP, TAZ, CAMTA1
Systemic therapies in advanced epithelioid haemangioendothelioma: A retrospective international case series from the World Sarcoma Network and a review of literaturehttps://pubmed.ncbi.nlm.nih.gov/33713582/2021treatment
Post-resection prognosis of patients with hepatic epithelioid hemangioendotheliomahttps://pubmed.ncbi.nlm.nih.gov/33748027/2021liver, hepatic, resection, surgery
Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of expertshttps://www.sciencedirect.com/science/article/pii/S20597029210013072021diagnosis, treatment, survival
Epithelioid hemangioendothelioma of bone: A survival analysis of 50 cases from the SEER database (1992–2016)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044559/?fbclid=IwAR2izt9tNl9Pb9J7ucff5JTduXAimTEnu2JRKIMWmSBk7p8yhxjm7gdXBuE2021bone, survival
Epithelioid Hemangioendothelioma and Epithelioid Hemangioma: Pazopanib as a Potential Salvage Therapyhttps://www.karger.com/Article/FullText/5108062021bone, treatment
Clinical prognostic factors in advanced epithelioid haemangioendothelioma: a retrospective case series analysis within the Italian Rare Cancers Networkhttps://pubmed.ncbi.nlm.nih.gov/33714008/2021survival, prognosis
Variant WWTR1 gene fusions in epithelioid hemangioendothelioma—A genetic subset associated with cardiac involvementhttps://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.228392020fusion
Treatment of Hepatic Epithelioid Hemangioendotheliomahttps://jamanetwork.com/journals/jamasurgery/article-abstract/4054672020liver, heptaic, treatment
TAZ-CAMTA1 and YAP-TFE3 modulate the basal TAZ/YAP transcriptional program by recruiting the ATAC histone acetyltransferase complexhttps://www.biorxiv.org/content/10.1101/2020.09.07.286633v1.full2020fusion, YAP, TAZ, CAMTA1
Systemic therapies in advanced epithelioid haemangioendothelioma (EHE): A retrospective international series from the World Sarcoma Networkhttps://oncologypro.esmo.org/meeting-resources/esmo-virtual-congress-2020/systemic-therapies-in-advanced-epithelioid-haemangioendothelioma-ehe-a-retrospective-international-series-from-the-world-sarcoma-network2020treatment
Soft‐tissue sarcoma in adults: An update on the current state of histiotype‐specific management in an era of personalized medicinehttps://doi.org/10.3322/caac.216052020treatment, diagnosis
Sirolimus for patients with progressive epithelioid hemangioendotheliomahttps://doi.org/10.1002/cncr.332462020treatment
Prognostic Stratification of Clinical and Molecular Epithelioid Hemangioendothelioma Subsets https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228463/2020survival, prognosis
Modulation of YAP/ TAZ by statins to improve survival in epithelioid hemangioendothelioma (EHE).https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.e235272020YAP, TAZ, survival, statin
Health-related quality of life and symptom burden of epithelioid hemangioendothelioma patients: a global patient-driven Facebook study in a very rare malignancyhttps://www.tandfonline.com/doi/full/10.1080/0284186X.2020.17666962020symptoms
Childhood Soft Tissue Sarcoma Treatmenthttps://www.ncbi.nlm.nih.gov/books/NBK65923/?report=reader2020treatment, pediatric
Activity of sirolimus in patients with progressive epithelioid hemangioendothelioma: A case‐series analysis within the Italian Rare Cancer Networkhttps://doi.org/10.1002/cncr.332472020treatment
1655P Immune signature and molecular profiling of epithelioid hemangioendotheliomahttps://www.annalsofoncology.org/article/S0923-7534(20)41877-0/fulltext2020diagnosis
Effective combined therapy for pulmonary epithelioid hemangioendothelioma: A case reporthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262721/2020pulmonary, treatment
The Role of Local Therapy in Multi-focal Epithelioid Haemangioendotheliomahttps://ar.iiarjournals.org/content/39/9/48912019treatment, surgery, ablation
Reconstruction of a Thoracic Spine Epithelioid Hemangioendothelioma with Antibiotic Impregnated Poly-methyl Methacrylate: A Case Reporthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823094/2019bone, spine
Imaging findings in epithelioid hemangioendotheliomahttps://www.clinicalimaging.org/article/S0899-7071(19)30107-X/fulltext2019pediatric, radiology
Ga-DOTA-E-[c(RGDfK)]2 positron emission tomography-computed tomography in the evaluation of hepatic hemangioendothelioma epithelioid.https://www.ncbi.nlm.nih.gov/pubmed/308284142019liver, hepatic, PET
Epithelioid hemangioendothelioma of the bone: A case report with findings of bone scintigraphyhttps://www.ncbi.nlm.nih.gov/pubmed/310832122019bone
Common Secondary Genomic Variants Associated With Advanced Epithelioid Hemangioendotheliomahttps://jamanetwork.com/journals/jamanetworkopen/fullarticle/27520872019fusion, CAMTA1
Unicentric epithelioid hemangioendothelioma of the calcaneus: a case report and review of literature.https://www.ncbi.nlm.nih.gov/pubmed/296326582018bone
The Feature of Solitary Small Nodular Type of Hepatic Epithelioid Hemangioendothelioma.https://www.ncbi.nlm.nih.gov/pubmed/301860922018liver, hepatic
Small, incidental hepatic epithelioid haemangioendothelioma the role of ablative therapy in borderline patients.https://www.ncbi.nlm.nih.gov/pubmed/301511132018liver, hepatic, ablation
Hepatic Epithelioid Hemangioendothelioma Presenting as an Enlarging Vascular Lesion within the Spleen.https://www.ncbi.nlm.nih.gov/pubmed/298503642018liver, hepatic
Diffuse hepatic epithelioid hemangioendothelioma with multiple splenic metastasis and delayed multifocal bone metastasis after liver transplantation on FDG PET/CT images: A case reporthttps://www.ncbi.nlm.nih.gov/pubmed/298517772018liver, transplant, hepatic, PET
Clinical characteristics of Japanese patients with epithelioid hemangioendothelioma: a multicenter retrospective study.https://www.ncbi.nlm.nih.gov/pubmed/303405592018treatment, prognosis
An Aggressive Large Epithelioid Hemangioendothelioma of the Anterior Mediastinum in a Young Womanhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301323/2018resection, surgery
A Case of Vanishing Metastatic Mass: Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine.https://www.ncbi.nlm.nih.gov/pubmed/301861362018bone, spine
Epithelioid Hemangioendothelioma: Update on Diagnosis and Treatmenthttps://link.springer.com/article/10.1007%2Fs11864-018-0536-y2018treatment
New Insights about Pulmonary Epithelioid Hemangioendothelioma: Review of the Literature and Two Case Reports.https://www.ncbi.nlm.nih.gov/pubmed/288840372017lung, pulmonary
New Insights about Pulmonary Epithelioid Hemangioendothelioma: Review of the Literature and Two Case Reportshttps://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.124742017lung, pulmonary
F-FDG PET/CT in Pleural Epithelioid Hemangioendothelioma.https://www.ncbi.nlm.nih.gov/pubmed/288401422017lung, pleura, pulmonary, PET
Epithelioid hemangioendothelioma of the spine: case report and review of the literature.https://www.ncbi.nlm.nih.gov/pubmed/287445092017bone, spine
Epithelioid hemangioendothelioma of the craniocervical junction; case report and reviewhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197577/2017bone, spine
Clinico-radiological features and next generation sequencing of pulmonary epithelioid hemangioendothelioma: A case report and review of literature.https://www.ncbi.nlm.nih.gov/pubmed/287774942017lung, pulmonary
Hepatic Epithelioid Hemangioendothelioma and Adult Liver Transplantation Proposal for a Prognostic Score Based on the Analysis of the ELTR-ELITA Registryhttps://journals.lww.com/transplantjournal/Fulltext/2017/03000/Hepatic_Epithelioid_Hemangioendothelioma_and_Adult.21.aspx2017liver, hepatic, transplant, treatment
Pazopanib in advanced vascular sarcomas: an EORTC Soft Tissue and Bone Sarcoma Group (STBSG) retrospective analysishttps://pubmed.ncbi.nlm.nih.gov/27838944/2016treatment, retrospective
Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoproteinhttps://www.nature.com/articles/onc20151482016fusion, TAZ, CAMTA1
Long term follow up after resection emphasizes the role of surgery in Primary Hepatic Epithelioid Hemangioendothelioma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995439/2016liver, hepatic, resection, surgery
Epithelioid hemangioendotheliomas with TFE3 gene translocations are compossible with CAMTA1 gene rearrangementshttps://doi.org/10.18632/oncotarget.70602016fusion, YAP, CAMTA1
Unraveling the Mysteries of Epithelioid Hemangioendothelioma: A Conversation with Dr. Brian Rubinhttps://www.ascopost.com/issues/february-10-2015/unraveling-the-mysteries-of-epithelioid-hemangioendothelioma/2015fusion
Pulmonary Epithelioid Hemangioendothelioma: Advances in Treatment Options Despite a Rare Vascular Tumorhttps://pdfs.semanticscholar.org/da36/0b4e23d39ad44ac7a9f6515c5283f80186f7.pdf2015lung, pulmonary, treatment
Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma-a suitable treatment option: case report and review of anti-angiogenic treatment options.https://www.ncbi.nlm.nih.gov/pubmed/259676762014lung, pulmonary, treatment
Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendotheliomahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051950/2014liver, hepatic, treatment
Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 caseshttps://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-9-1312014fusion, YAP, TAZ, diagnosis
Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumorhttps://pubmed.ncbi.nlm.nih.gov/25992243/2014diagnosis, treatment, survival, symptoms
Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145773/2014liver, transplant, hepatic
Clinicopathological characteristics of pulmonary epithelioid hemangioendothelioma: A report of four cases and review of the literaturehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214485/2014lung, pulmonary
Cervical spine epithelioid hemangioendothelioma: case reporthttps://www.europeanreview.org/article/72732014bone, spine
A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendotheliomahttps://www.ncbi.nlm.nih.gov/pubmed/247160522014bone, treatment
Treatment sequencing strategy for hepatic epithelioid haemangioendotheliomahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105907/2013liver, hepatic, treatment
Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: Report of three cases and review of the literaturehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678532/2013lung, pulmonary, treatment,
Sorafenib in patients with progressive epithelioid hemangioendothelioma: a phase 2 study by the French Sarcoma Group (GSF/GETO)https://pubmed.ncbi.nlm.nih.gov/23589078/2013clinical trial
Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendotheliomahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089994/2013fusion, YAP
Hepatic Epithelioid Hemangioendothelioma Treated With Irreversible Electroporation and Antibioticshttps://ascopubs.org/doi/10.1200/JCO.2012.44.97362013liver, heptatic, treatment, IRE
An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomashttps://www.annalsofoncology.org/article/S0923-7534(19)37035-8/fulltext2013clinical trial
Metastatic Pulmonary Epithelioid Hemangioendothelioma: A case report and review of the literaturehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920373/2012lung, pulmonary
Activity of Angiogenesis Inhibitors in Metastatic Epithelioid Hemangioendothelioma: A Case Reporthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643649/2012bone
Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Noduleshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160144/2011lung, pulmonary, PET
Multicentric Epithelioid Hemangioendothelioma Involving the Same Lower Extremity: A Case Report and Review of Literaturehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180772/2011bone
Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendotheliomahttps://stm.sciencemag.org/content/3/98/98ra822011fusion
Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancerhttps://journal.chestnet.org/article/S0012-3692(11)60600-4/fulltext2011lung, pulmonary
A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264678/2011fusion, CAMTA1
Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical managementhttps://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/lt.219642010liver, transplant, hepatic, treatment
Successful treatment of metastatic hepatic epithelioid hemangioendothelioma with thalidomide: a case reporthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022673/2010liver, hepatic, treatment
Primary pleural epithelioid hemangioendothelioma (EHE) – two cases and review of the literaturehttps://apps.dtic.mil/dtic/tr/fulltext/u2/a528388.pdf2010lung, pleura, pulmonary
Liver transplantation and vascular tumours.https://onlinelibrary.wiley.com/doi/full/10.1111/j.1432-2277.2010.01107.x2010liver, transplant, hepatic
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumorhttps://pubmed.ncbi.nlm.nih.gov/20485168/2010VEGF
Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997660/2010liver, transplant, hepatic, treatment
Treatment of Hepatic Epithelioid Hemangioendothelioma A Single-Institution Experience With 25 Caseshttps://jamanetwork.com/journals/jamasurgery/fullarticle/4054672009liver, hepatic, treatment, retrospective
Liver transplantation for hepatic epithelioid hemangioendothelioma: the Canadian multicentre experience.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661301/2008liver, hepatic
Epithelioid Hemangioendothelioma of the Head and Neck: Role of Podoplanin in the Differential Diagnosishttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807604/2007treatment
The place of liver transplantation in the treatment of hepatic epitheloid hemangioendothelioma: report of the European liver transplant registryhttps://pubmed.ncbi.nlm.nih.gov/18043096/2007liver, hepatic, transplant
Primary malignant hepatic epithelioid hemangioendothelioma A comprehensive review of the literature with emphasis on the surgical therapyhttps://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.222252006liver, hepatic, transplant, surgery
Management of hepatic epithelioid haemangioendothelioma in children: what option?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409708/2004liver, hepatic, pediatric
Vascular tumors of bone: A study of 17 cases other than ordinary hemangioma, with an evaluation of the relationship of hemangioendothelioma of bone to epithelioid hemangioma, epithelioid hemangioendothelioma, and high-grade angiosarcomahttps://pubmed.ncbi.nlm.nih.gov/12874764/2003bone
Hepatic epithelioid hemangioendothelioma: resection or transplantation, which and when?https://aasldpubs.onlinelibrary.wiley.com/doi/epdf/10.1002/lt.5000506121999liver, transplant, hepatic, resection, surgery
Long Term Results Following Liver Transplantation For Primary Hepatic Epithelioid Hemangioendotheliomahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975485/1995liver, transplant, hepatic, survival
Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinomahttps://acsjournals.onlinelibrary.wiley.com/doi/10.1002/1097-0142(19820901)50:5%3C970::AID-CNCR2820500527%3E3.0.CO;2-Z1982diagnosis
Towards a Proper Diagnosis and Understanding of Epitheliod Hemangioendotheliomahttp://sarcomahelp.org/research/epithelioid-hemangioendothelioma.htmlfusion, CAMTA1, diagnosis