EHE Research Updates
EHE Mouse Model
Currently, there is no known mouse model available for EHE. Over the past two years, Dr. Rubin worked diligently with other specialists to produce a genetically modified mouse model affected by EHE. Dr. Rubin accomplished this by genetically modifying the mice so they have the key WWTR1(TAZ)-CAMTA1 EHE gene mutation and will produce the fusion gene that is believed to drive EHE. In early 2017, Dr. Rubin’s team managed to achieve germline transmission of the gene mutation in the mice (the transfer of the gene mutation from the parents to their young during reproduction). These mice were bred and allowed to grow, and Dr. Rubin’s team will soon sacrifice some of the mice for the first time to see if they developed EHE tumors. If they have, we may finally have an EHE mouse model that can be bred and shared with other interested researchers to understand the disease. Of course, this would of course be a huge step forward.
Therapeutic Drug Screening
Dr. Che in Dr. Rubin’s team has been working to develop a drug screening assay to test a large number of potentially therapeutic compounds to see if they have any impact on the WWTR1(TAZ)-CAMTA1 fusion protein that is believed to be a key driver of EHE. The assay is now complete and screening is underway! This project also has a special place for our group as Dr. Che is the post-doc that Dr. Rubin was able to recruit with the funds we provided in 2016.
Mekinist Drug Trial
2017 saw the launch of the Mekinist (Trametinib) clinical trial for EHE patients with progressing EHE. This is the multi-institutional-trial that Dr Rubin had alerted the group to earlier in the year. The trial is led by Dr Schuetze from University of Michigan who is the Principal Investigator. This trial is designed based on Dr Rubin's preclinical research on EHE biology. The first arm of the trial is complete and we are waiting for the results. If at least one patient shows at least 30% shrinkage, the second arm of the trial will be open. We are also supporting this trial financially as our EHE group provided funding for the biopsies that Dr Rubin hopes patients will agree to, so the real impact of Mekinist on EHE cells can be understood.
As part of The EHE Foundation’s patient support role, the group has also established a confidential closed Facebook page for patients taking part in the study, so that they may be able to assist each other as they continue through the trial. We wish them all success as they participate in this important trial.
Circulating Biomarkers Program
One of the biggest challenges we face dealing with EHE is that sometimes patients are progressing without significant changes on their scans, and the window of opportunity for prompt initiation of treatment is missed. Therefore, The EHE Foundation initiated discussion about Circulating Biomarkers program in collaboration with Mayo Clinic. There are several blood circulating biomarkers that might be useful for monitoring EHE progression (or response to treatment), so we are focusing on circulating DNA as a first step. The discussions are ongoing with Dr. M. Liu from Mayo Clinic.
Tissue and Blood Biobank
Tissue availability for research is a real challenge with rare cancers. Our research coordinator Denise Robinson has teamed up with Dr. Rubin to establish EHE tissue /blood bank and they are making significant progress.